Caleb Huse was born in New York and graduated from the United States Military Academy at West Point. Although a native of Massachusetts, he had deep Southern sympathies after serving as a professor of chemistry at the University of Alabama, where he was also commandant of its corps of cadets.
Huse was deployed to London by the Confederate Government to serve as a purchasing agent for the army. In this role he purchased over £10 million worth of rifles, artillery pieces, and other weaponry, all of which had to be snuck through the US naval blockade of the Southern coast.
After the war Huse remained living at his Notting Hill home until 1868, when he returned to the United States to live in New York, where he died in 1905 at Highland Falls.